University of Cincinnati researchers have determined why a certain class of diabetes drugs leads to weight gain and have found that the molecular system involved (PPAR-γ found in the brain) is also triggered by consumption of high-fat foods. The study could lead to the modification of existing diabetes therapies and even dietary recommendations to limit the action of this nuclear receptor in the brain.

Read more http://www.eurekalert.org/pub_releases/2011-05/uoca-sib042811.php